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Patients at risk of hypoglycaemia (particularly those on insulin or sulfonylureas) must follow DVLA guidance, including testing glucose before driving and every 2 hours during longer journeys
GLP-1s are compatible with this approach
Furthermore, semaglutide prevents MASLD/MASH-driven HCC progression in metabolic preclinical models, partly by correcting adipokine imbalances (low adiponectin, high leptin) associated with insulin resistance, which removes a key chronic inflammatory and pro-oncogenic signal linked to the disease ( It is important to note that most of the evidence supporting the anti-tumor efficacy of GLP-1 RAs is derived from preclinical studies, including in vitro studies and animal experiments demonstrating reduced proliferation of the cancer cells, enhanced apoptosis, and modulation of oncogenic signaling pathways ( These systemic and direct molecular effects, particularly the potent anti-inflammatory actions and metabolic correction, are highly relevant to mitigating the progression of both ALD and MetALD
These could be hospital records indicating visits due to persistent nausea, abdominal bloating among others which are typical signs of gastroparesis
Some emerging studies are showing that it may be possible for patients to taper off of weight loss drugs or take lower doses and maintain a lower BMI
