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The question of how long semaglutide takes to work depends on the outcome you are measuring

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The most common side effects are gastrointestinal: nausea, vomiting, abdominal discomfort, diarrhea, or constipation

Ultimately, initiating GLP-1 therapy before full thyroid optimization is a clinical judgment call that should weigh the urgency of metabolic control against the risk of confusing the symptoms or destabilizing thyroid function