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Furthermore, the nicotine concentration level (~ 6.57 g/ml) obtained per well in our studies related with previous smoke exposure reports utilizing the 1R6F cigarettes 57,58 , although future in-depth studies are required to standardize the in vitro to in vivo smoker dose correlation to better assess human smoking responsiveness

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2), the urinary nicotine and cotinine levels decreased to 1.8 and 3.4% after quitting smoking for 2 weeks, and then to 1.7 and 0.2% after 8 weeks, relative to the values at the beginning of the smoking cessation program