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A precision-targeted therapy system targeting CD24 was designed to enhance cell ferroptosis and macrophage phagocytosis through the NF2-YAP signaling axis by inhibiting FSP1 and CD24, ultimately leading to cell death, inhibiting TNBC tumor growth, and potentially eliminating certain tumors (113)

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Drug Interactions The concomitant use of JANUMET with specific drugs may increase the risk of metformin-associated lactic acidosis: those that impair renal function, result in significant hemodynamic change, interfere with acid-base balance or increase metformin accumulation [see Drug Interactions (7)]

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