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According to the MHRA SmPC, Wegovy can cause a small mean increase in heart rate (approximately 24 beats per minute) with individual variability

The allowance for investigators to use all available information (for example, concomitant medication) to assess glycemic category was primarily included to account for scenarios in which glucose-lowering medications were initiated during the trial that would confound glycemic category assessment if based purely on fasting plasma glucose or HbA 1c levels (for example, if a patient developed diabetes during the study and received a glucose-lowering drug that resulted in their glucose level being below the American Diabetes Association threshold for type 2 diabetes diagnosis)

Semaglutide serves as a strategic cornerstone in combination diabetes therapies, working synergistically with metformin, insulin, and SGLT2 inhibitors to enhance glycemic control, promote weight loss, and reduce cardiovascular risks

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