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Retatrutide, a triple agonist targeting gastric inhibitory polypeptide (GIP), GLP-1, and glucagon receptors, has achieved highly promising outcomes in its phase 2 trial [22], with weight loss up to 24%

The recommended dosage is 1.75mg injected under the skin

While this slowing helps reduce appetite and blood sugar spikes, delayed gastric clearance can increase intragastric pressure and reflux frequency

doi: 10.1074/jbc.M112.426288 73 PathakVGaultVAFlattPRIrwinN

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