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Sikiri P, Gyires K, Seiwerth S, Grabarevl Z, Ruman R, Petek M, Rotkvi I, Turkovi B, Udovi I, Jagi V, Mildner B

The discovery that NNMT expression is dramatically elevated in adipose tissue of obese humans and animal models, and that NNMT inhibition or knockdown prevents diet-induced obesity and improves metabolic health, has catalyzed intense research interest in NNMT as a therapeutic target for obesity, metabolic syndrome, and related conditions

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High levels of reactive oxygen species directly sensitize mast cells, altering their intracellular calcium levels and provoking them into inappropriate, constant degranulation