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The Diabetes Prevention Program showed that intensive lifestyle intervention reduced diabetes incidence by 58%, outperforming metformin

It is a peptide similar to the hormone glucagon-like peptide-1 (GLP-1) but modified with a side chain

Similarly, mice exposed to CUMS for 6 weeks showed an increased interferon-gamma (IFN-) and decreased anti-inflammatory IL-10 levels, demonstrating anti-inflammatory suppression with further pro-inflammatory activation (Jia et al., 2024)