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Far from being a static microenvironment, pericardial fluid not only provides homeostatic support to the heart, but also dynamically reflects cardiac injury and regulates its function by stocking bioactive molecules, some of which have been identified including cytokines, chemokines, growth factors, matrix metalloproteases (MMPs), or lipid mediators 38,39,40,46

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While their full MoA remains to be elucidated, it is known that they can activate Nrf2