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For example, a study published in Health Affairs found that community health worker interventions addressing social determinants of health yielded an ROI of $2.47 for every dollar invested in Medicaid populations, with returns consistently ranging from $1.84 to $3.09 per dollar invested when researchers varied their analysis

Neuropsychopharmacology 40 , 15691579 (2015)

There are also three records of patient deaths following self-administered coffee enemas