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These data revealed Np63 binds to the promoters or enhancers of PHGDH, PSAT1, PSPH and SLC1A4, which correspond to open chromatin regions, as indicated by H3K27 acetylation (H3K27ac) (Fig

Blocking downstream sensing pathways Despite a reduction in mtDNA release, residual cytosolic or extracellular mtDNA can activate innate immune receptors to sustain inflammation

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During oxidative phosphorylation, the electron transport chain in the inner membrane produces a large number of ROS [81]

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