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Constipation: Reported by about 21% of participants
These groups received intravenous treatments of PBS, oridonin, orid-liposome, orid-liposome-MAL, TLR2 pep-orid-liposome at a dose of 5 mg/kg, or PBS as control every other day
Intravenous: Used in one pilot study but not recommended for mental health applications and requires medical supervision
Glucagon-like peptide-1 (GLP-1) receptor agonists, including semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound), work through multiple mechanisms that influence gastric function
3 To bolster supply chain security, the agency maintains a green list import alert (66-80) to prevent GLP-1 active pharmaceutical ingredients (APIs) with quality concerns from entering the U.S., while still allowing legal importation from compliant manufacturers
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