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Gallbladder problems - Some people taking Ozempic have reported experiencing gallbladder problems like gallstones and inflammation

While semaglutide reduces appetite in most users, weight gain occurs when calorie intake exceeds expenditure despite medication, often from tolerance development, compensatory overeating during symptom plateaus, or increased insulin sensitivity driving food calories into fat storage

SURMOUNT and STEP clinical trial data on weight plateau management

In its phase 2 trial, retatrutide improved blood pressure, lipids, and glycemia as secondary endpoints, consistent with its weight effect though these are early, secondary findings in a relatively small study

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