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Inhibition of LCTs with reverse transcriptase inhibitors, a class of agents commonly used in HIV and HBV, has shown promising results in clinical studies and would affect tumor progression and metastatic dissemination [18]

This often leads to painful and/or disruptive symptoms in the feet and lower legs but these symptoms may also progress to other parts of the body

This metabolite acts as a nutrient source for colonocytes

The SURMOUNT-1 trial protocol allowed one dose de-escalation for intolerable side effects, which underscores that slower titration is acceptable and sometimes preferred

[7] [8] NICE technology appraisal TA875 supports its use within specific NHS commissioning criteria, which differ from the licensed indication