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FIGURE 1 The erasure/re-establishment of DNA methylation during early embryogenesis aids in the process of cell differentiation (Straussman et al., 2009)

Marcus, doctoral student4, Charlotte Probst, assistant professor1 5 6, William A Lopez-Arboleda, consultant1, Cara Ebert, researcher7, Christian Bommer, research associate1 4, Maya Mathur, assistant professor, Glennis Andall-Brereton, independent consultant, Silver K Bahendeka, professor10, Pascal Bovet, associate professor11 12, Farshad Farzadfar, professor13, Erfan Ghasemi, unit head13, Mary T Mayige, principal research scientist14, Sahar Saeedi Moghaddam, researcher15, Kibachio J Mwangi, medical advisor16 17, Shohreh Naderimagham, project manager13, Lela Sturua, department head18, Rifat Atun, professor19 20, Justine I Davies, professor21 22, Till Brnighausen, professor1 19 23, Sebastian Vollmer, professor4, Pascal Geldsetzer, assistant professor 24 25 1 Heidelberg Institute of Global Health, Heidelberg University, Heidelberg, Germany 2 Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA 3 Medical Practice Evaluation Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA 4 Department of Economics and Centre for Modern Indian Studies, University of Goettingen, Gttingen, Germany 5 Institute for Mental Health Policy Research, Centre for Addiction and Mental Health (CAMH), Toronto, ON, Canada 6 Department of Psychiatry, University of Toronto, Toronto, ON, Canada 7 RWI Leibniz Institute for Economic Research, Essen (Berlin Office), Germany 8 Quantitative Sciences Unit and Department of Pediatrics, Stanford University, Stanford, CA, USA 9 Port of Spain, Trinidad and Tobago 10 St Francis Hospital, Kampala, Uganda 11 Ministry of Health, Victoria, Seychelles 12 University Center for Primary Care and Public Health (Unisant), Lausanne, Switzerland 13 Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 14 National Institute for Medical Research, Dar es Salaam, Tanzania 15 Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran 16 Division of Non-Communicable Diseases, Ministry of Health, Nairobi, Kenya 17 Institute of Global Health, Faculty of Medicine, University of Geneva (UNIGE), Geneva, Switzerland 18 Non-Communicable Disease Department, National Center for Disease Control and Public Health, Tbilisi, Georgia 19 Department of Global Health and Population, Harvard TH Chan School of Public Health, Boston, MA, USA 20 Department of Global Health and Social Medicine, Harvard Medical School, Harvard University, Boston, MA, USA 21 MRC/Wits Rural Public Health and Health Transitions Research Unit, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa 22 Institute of Applied Health Research, University of Birmingham, Birmingham, UK 23 Africa Health Research Institute, Somkhele, South Africa 24 Division of Primary Care and Population Health, Stanford University, Stanford, CA, USA 25 Chan Zuckerberg Biohub, San Francisco, CA, USA Correspondence to: Pascal Geldsetzer [email protected] Accepted 1 July 2022 Abstract Objectives To determine the prevalence and frequency of using any tobacco product and each of a detailed set of tobacco products, how tobacco use and use frequency vary across countries, world regions, and World Bank country income groups, and the socioeconomic and demographic gradients of tobacco use and use frequency within countries

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1955-1959 Between 1955 and 1959, Marlboro refined its logo into the iconic form that became instantly recognizable worldwide