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Tobacco that has simply dried out or lost flavor is safe to smoke, though it may not be enjoyable

Animal study design Adult female sheep (ewes) were used in all experiments because male sheep are naturally more aggressive and thus not amenable for long-term experimentation without the use of general anesthesia

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The total number of dendritic cells, CD4+ T cells (including regulatory T cells) and CD8+ T cells was significantly increased following exposure to cigarette smoke for 24 weeks (25)

Tobacco use remained the leading risk factor contributing to the fatal disease burden, with the study estimating that it was responsible for 11.7% of the years of life lost