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The proposal to modify the current diagnostic criteria also derives from the observation that in 15 out of 16 patients of our cohort who did not satisfy the major criterion 1 (and consequently neither the minimal criteria for genetic testing), this was due to the absence of generalized skin hyperextensibility

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Where a direct data series was missing for a smaller country, we used proxy ratios from comparable markets and then adjusted them based on interview feedback and trade indicators

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