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Additionally, nicotine enters the brain and blood within seconds and leaves the body within hours, causing most smokers to experience nicotine withdrawal symptoms while trying to sleep

Gendall P, Hoek J, Edwards R, McCool J: A cross-sectional analysis of how young adults perceive tobacco brands: implications for FCTC signatories

After quitting smoking, participants who were abstinent at the 12-month follow-up had a mean reduction of 8.09 in their BDI-II scores from pre-intervention to the last follow-up, indicating an improvement of depressive symptomatology over time

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