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Although FDA announced prioritized enforcement of required pre-market authorization for all ENDS products, the agency was unable to regulate ENDS products created with synthetic nicotine until Congress enacted a new law in April 2022 granting FDA authority to regulate tobacco products containing nicotine of any source

Nicotine promotes the local release of norepinephrine within body tissues and systemic release of epinephrine from the adrenal glands

Office of Surgeon General of the United States

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