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[52] In addition, substantial evidence implicates bile acids as an important factor in colon cancer

Since many of the cases in North America were traced to THC cartridges as well as the use of e-cigarette vape products, but THC remains illegal in European countries, the disease burden related to vaping has been significantly lower in Europe despite the prevalence of e-cigarette use

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Nicotine does not contribute to smoking-related diseases and it is not classified as a carcinogen by the International Agency for Research on Cancer (WHO-IARC, 2004)