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John Britton of the Royal College of Physicians and his co-authors said in a summary of the published in the BMJ

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What most people remember about Gehrig, thanks to Gary Coopers portrayal in The Pride of the Yankees, is his simple, decent, sweet, uncomplaining, stoic response to this awful disease, which ravaged a once virile man until he could not walk or speak or swallow

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In reality, its a continuum of exposure, he says