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Unfortunately, if the compound manipulation is not cautious, the liposomes can 'break,' releasing the vitamin, which is a big problem because although it remains liposomal vitamin in origin, in practice it is no longer protected

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A recent meta-analysis studied 13 OCT2 variants with varying frequency and its impact of metformin efficacy in a mixed ethnic cohort, among which one variant (rs316019) displayed both positive and negative effects in pharmacokinetics and pharmacodynamics of the drug (Peng et al., 2023)