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Results The global and regional burden of LCAS in 2021 Globally, the LCAS burden in 2021 amounted to 2,061,113 DALYs (95% UI: 1,838,5882,281,339) and 72,740 deaths (95% UI: 64,99280,488), with a corresponding age-standardized death rate (ASDR) of 23.38 per 10,000 population (95% UI: 20.8425.89) and an age-standardized mortality ratio (ASMR) of 0.89 per 10,000 population (95% UI: 0.800.99) (Table 1)

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