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However, upon conformational changes in KEAP1 resulting from the oxidation of cysteine residues, Nrf2 is stabilized and moves into the nucleus, binding the antioxidant-responsive element (ARE) in the promoter region (Figure 4) (Yamamoto et al., 2018)

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Similar content being viewed by others Introduction Cigarette smoking has long been established as a cardiovascular risk factor and is the major preventable cause of death and disability in developed and developing countries

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Which method matters depends on the question Use nicotine content (Method 1) if you're tracking total exposure over the life of a device, comparing products, or stepping down strength as part of a quit plan