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Smoking cessation and incident dementia in elderly Japanese: the Ohsaki Cohort 2006 Study

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Modified Risk Tobacco Product (MRTP) orders for 20 variants of ZYN, allowing the company to market the products with the claim: "Using ZYN instead of cigarettes puts you at a lower risk of mouth cancer, heart disease, lung cancer, stroke, emphysema, and chronic bronchitis." The company said the decision makes ZYN the first nicotine pouch product to receive FDA authorisation for reduced-risk marketing claims

They then identified the chemicals released using gas chromatography/mass spectrometry and compared the levels of inflammation and cell damage to human lung cells after exposure to 55 puffs of tobacco smoke or e-cigarette vapor