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Occurs after small doses (reduces the likelihood that the reaction is due to dose-related drug toxicity) Occurs with other drugs that are chemically or immunologically similar to the suspected drug Produces signs and symptoms that differ from the usual pharmacologic actions of the suspected drug Produces signs and symptoms usually considered allergic in nature (e.g., anaphylaxis, urticaria, serum sickness) Produces similar signs and symptoms to previous allergic reactions to the same or a similar drug Increases eosinophils in blood or tissue Resolves within a few days of discontinuing the suspected drug Virtually all drugs have been implicated in anaphylactic reactions

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1977 [x] The Vancouver Sun, Nov 4, 1977 [xi] When the Going Gets Weird, p.168 [xii] [xiii] [xiv] Detroit Free Press, March 24, 1974 [xv] Outlaw Journalist, p.150 [xvi] E-mail, March 2024 [xvii] [xviii] [xix] [xx]

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