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During the healing stage of HSV infection on the tongue dorsum, lesions are often depressed granulating ulcers with sharply demarcated borders, a condition referred to as herpetic geographic glossitis. Oral recrudescent varicella-zoster virus usually presents as clustered ulcers affecting one side of the mouth but atypical findings may be noted in patients who are immunocompromised

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It was also observed that ET-1 is involved in activation of protein kinase C (PKC), which phosphorylates subunits of the NADPH oxidase complex to create the active, superoxide producing, state [46]

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