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Experimental The reference cigarettes 3R4F were supplied by the University of Kentucky and conditioned according to the ISO 3402 standard (12) (at least 48 h at 60% relative humidity and 22 C)

The direct cause of the burning pain is the inflammation or irritation of the throat, triggered by various illnesses, conditions and diseases

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Designs vary, but the devices generally contain a power source (typically a lithium battery), a heating element, and a reservoir for the e-liquid (Figure 1)

Women are currently recommended to stop smoking and limit their caffeine intake during pregnancy because of the risk of complications to the baby