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A word on biotin, which comes up in every other community discussion: in people without a confirmed biotin deficiency there is no solid evidence that it works

doi: 10.1093/geronj/43.4.B102 63 BartkeAWrightJCMattisonJAIngramDKMillerRARothGS

Choline and its metabolites are differently associated with cardiometabolic risk factors, history of cardiovascular disease, and MRI-documented cerebrovascular disease in older adults

Whether you run a continuous protocol or cycle on/off periods, nocturnal administration remains optimal during active phases

The effect may be mediated more through local neural signaling than through systemic hormone levels