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The wide disparity in rates among states and cities is a significant factor in increased cigarette smuggling across the country

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Adjunctive therapies, such as localized antimicrobial agents or laser-assisted treatments, may be used to further reduce inflammation and bacterial load

A Family Smoking Prevention and Control Act in 2009 finally provided the FDA with regulatory control over tobacco, as well as the ability to reduce nicotine levels (although not to zero)