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Second, the participants in this study exclusively used e-cigarettes and possessed a strong desire to quit, so it is unclear what the effects of varenicline may be in a population who may smoke tobacco and use e-cigarettes or is uninterested in quitting

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Further details are described in Gonalves-Silva et al

Advantages of a Refillable Vape Pen: More cost-effective over time since you only replace the coil or pod and the e-liquid or oil