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The combination of high nicotine concentrations delivered efficiently to a physiologically vulnerable adolescent population raises significant concern for both acute events (in susceptible individuals) and the long term development of cardiovascular disease (10, 1214)

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Small changes in weather or household conditions can still affect pollutant levels over time

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[6] While many local-level policies restricting the sale of flavored tobacco products have similarly made exceptions for menthol, that trend is beginning to change