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Given that smoking one to two puffs of a cigarette results in 50% occupancy of the 4 2 -containing nicotinic cholinergic receptors, whereas smoking a full cigarette (or more) leads to over 88% receptor occupancy and a reduction of cigarette craving (Brody et al , 2006), the present results suggest that menthol is likely to increase the rate at which the receptor occupancy reaches a level that leads to significant behavioral effects in male smokers

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