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MUC5AC and MUC5B are the most expressed mucins, with MUC5AC predominantly expressed in goblet cells and MUC5B in submucosal glands ( Club cells are found in the small airways and their gene expression is closely related to that of basal cells ( 3 The basement membrane and cell-cell connections The airway epithelium is a pseudo-stratified layer with clear apical and basolateral aspects that play a role in intercellular signalling ( Adherens and tight junctions are complexes that regulate the airway epitheliums permeability and maintain its barrier function against foreign antigens that are not cleared by the muco-ciliary system ( Figure 1 )

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