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Shortterm effects (minutes to hours) Euphoria or numbness followed by confusion, anxiety, or fear Distorted sights, sounds, and body perception Poor coordination and slurred speech Agitation , impulsivity, or violent behavior Nystagmus (rapid, sidetoside eye movements)a classic red flag clinicians look for Increased heart rate and blood pressure

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To further validate the effect of NF-B, we subjected Nfb1 mutant mice to ATSE and abrasion