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Similarly, overexpression of IRAK-M (a negative regulator of TLR-mediated immune responses) in human macrophages through JAK2/STAT3/PI3K not only mediates the anti-inflammatory effect of nicotine via 7nAChRs but also triggers the hyperresponsivity [134]

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The Global Adult Tobacco Survey 2017 revealed that 28.6% (around 266 million) of adults in India, aged 15 and above, currently use tobacco in some form