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There were 69 subjects in the placebo group and 62 in the hydrolyzed collagen group

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A dense extracellular matrix (ECM), rich in collagen and hyaluronic acid, forms a physical barrier that restricts drug penetration and distribution

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Importantly, low Se levels in pregnant women affect fetal growth and augment the risk of delivering a small-for-gestational age infant by reducing placental antioxidant defense, while low Se in the third trimester is thought to indicate increased demands by the placenta, an issue which requires further confirmation