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What neither planters nor laborers fully understood at the time was the degree to which Virginia's farms were integrated into a national market economy

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Techniques exist for estimating the magnitude and direction of potential biases introduced by a differentially misclassified confounder, based on sensitivity and specificity estimates from an internal validation sub-study or a range of plausible values derived from an external validation study such as this (see e.g

Rapid Commun Mass Spectrom 18, 25492557 (2004)