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Both of these effects would be expected to increase reflux

Neurology 44:10901096 Pelissier-Rota MA, Pelosi L, Meresse P, Jacquier-Sarlin MR (2015) Nicotine-induced cellular stresses and autophagy in human cancer colon cells: A supportive effect on cell homeostasis via up-regulation of Cox-2 and PGE(2) production

Whereas the American Dialect Societys 2007 word, subprime, makes lasting sense, the year before it chose plutoed to be demoted which clearly hasnt stood the test of time, adorkable (yes, a 2014 addition to the Collins dictionary) though it is