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Lepr db/db , diabetes (db) mutation of the leptin receptor, a Various mouse models were crossed to C57BL/6 background for mechanistic studies, including T1/ST2-deficient mice, IL-33 citrine reporter mice, and IL-33 deficient mice

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82 Glutamate Glutamate is the main excitatory neurotransmitter in the central nervous system (CNS) 83 and can be released by neurons through exocytosis, which in turn activates extracellular N-methyl-D-aspartate receptors (eNMDARs) in neurons, leading to synaptic loss

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One role of GLP-1 is to prompt the body to produce more insulin, which reduces blood (sugar)