It has been observed that combining NRT strategies increases quit rates by 25% compared to NRT monotherapy, according to a 2022 article by Gaddey et al., published in the journal American Family Physician , titled Smoking Cessation Interventions . Varenicline delivered over a 4-week period has been found to be more effective at producing abstinence than bupropion and placebo, according to a 2024 article by Onwuzo et al., published in the journal Cureus , titled A Review of Smoking Cessation Interventions: Efficacy, Strategies for Implementation, and Future Directions . The abstinence rate for patients on Varenicline was 44% while those for bupropion and placebo were 29.5% and 17.7%, respectively
Articles and papers published from 1966 to 2013 formed the basis of the literature search across Medline, Embase, regional bibliographies of the WHO and even personal contact with clinical researchers to highlight other key texts
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