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Consistent with the notion that structural alterations in these regions are a product of prolonged nicotine/tobacco exposure, group differences between smokers and nonsmokers within, for example, the insula were not detected among an adolescent/young adult participant sample with relatively lower exposure levels (0.9 0.7 pack-years on average) [85] but were observed among similarly aged individuals with relatively higher exposure levels (4.0 1.8 pack-years) [86]

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Citation on PubMed Hakim A