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A retrospective study found that uPA and uPAR expression was significantly increased in pulmonary macrophages and alveolar wall cells from patients with COPD compared to the control, and that uPA expression was positively correlated with collagen levels [173]

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In 2017, Chaloupka reviewed research linking taxed cigarette sales in states that changed their taxes and their neighboring states and found that such tax avoidance practices are relatively uncommon