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3 In 1964, the Surgeon General of the United States concluded that cigarette smoking causes laryngeal and lung cancers

Consent for publication Not applicable, as the study did not involve individual-level identifiable data

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As a result, smokers often metabolise caffeine faster than non-smokers and often require a higher caffeine intake to achieve the same stimulant effects

Those smokers were compared with 50 other smokers who had damage to other parts of the brain but not their insula