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As to whether those who smoke e-cigarettes should be concerned, Kreiss had a one-word answer: "Absolutely." Diacetyl (pronounced die-AS-i-til), also known as butanedione, is found naturally in low concentrations in foods such as butter and beer, and is a byproduct of fermentation

And then the Center for Drug Evaluation and Research would determine whether the evidence is strong enough to warrant an indication as a drug

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Although e-cigarettes may not contain the multitude of carcinogens and toxic compounds known to be contained within traditional tobacco cigarettes, their potential to induce OS and negative impact on the BBB was considered not be significantly different as compared to traditional tobacco products [27]