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This denotes a similar condition as during aging-induced oxidative stress and the ability to recycle ascorbic acid during cigarette smoke-induced oxidative stress causes an upregulation in the PMRS levels in rats 27

Unfortunately, quitting smoking can be challenging due to uncomfortable physical withdrawal symptoms, such as nicotine cravings, irritability, difficulty concentrating, depression, insomnia, and increased appetite

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However, little is known about the chronic effects of cigarette smoking on the resting state spontaneous activity with a relatively large sample size, especially less was known about the association between the resting state abnormalities and cigarette smoking measures, which was very important to improve the understanding of the neural mechanism in smokers