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Abbreviations CB1 / CB2: Cannabinoid receptor 1 / cannabinoid receptor 2 CBD: Cannabidiol CCU: Chronic cannabis use CRP: C-reactive protein ECS: Endocannabinoid system MDMA: 3,4-Methylenedioxymethamphetamine MDSC: Myeloid-derived suppressor cells MWAS: Methylome-wide association study NCU: Non-cannabis-using NK cells: Natural killer cells PBMC: Peripheral blood mononuclear cell SUD: Substance use disorder THC: Trans-9-tetrahydrocannabinol WBC: White blood cell References UNODC: World Drug Report 2022

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[1] : 26 Additionally, some flavorings in cigarettes contain toxic compounds such as alkenylbenzenes

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