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Haplotypes with copy number and single nucleotide polymorphisms in CYP2A6 locus are associated with smoking quantity in a Japanese population

However, most studies that have looked at this association have not been able to disentangle whether this is a cause-and-effect relationship, and if so in which direction

The nicotine concentration depends on the brand and the product, ranging from 0 mg/ml to 24 mg/ml and may be labelled as nicotine-free, or referred to as mild/low, regular/medium or strong/high

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