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countries that report prevalence of adults using e-cigarettes include 0.3% in Indonesia, 1.2% in Italy, 1.9% in Greece and 5.9% in Poland.3 The value of global sales of e-cigarettes was estimated to be 3.5 billion US$ in 2015,4 with the largest three markets being the USA, Russia and Germany (collectively representing 60% of global sales).5 E-cigarette products have been marketed by manufacturers as alternative products to combustible tobacco that can be used when cigarettes are not permitted,6 or instead of cigarettes.7 A number of global tobacco control researchers have stated that e-cigarettes are less harmful than combusted tobacco;812 however, the impact of e-cigarettes on public health is unclear