A previous study comparing the conditional mutations of p53 LSL-R270H , p53 LSL-R172H and the p53 fl/fl allele in the Kras LSL-G12D/+ mouse model of LUAD revealed that while for all alterations the LOF effects were sufficient to promote Kras -initiated LUAD and drive metastasis to regional lymph nodes and distant organ sites, such as kidney in a small number of mice, the transcriptional processes governed by p53 to elicit this metastatic phenotype is however poorly understood
Available from: Bott U, Jrgens V, Grsser M, Bender R, Mhlhauser I, Berger M (1994) Predictors of glycaemic control in type 1 diabetic patients after participation in an intensified treatment and teaching programme
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Yet a new analysis that pools data from more than a dozen published studies finds that adolescents who are prescribed stimulant medications to treat ADHD are less likely to smoke than those with ADHD who are not treated with the drugs
